Comparative Modeling in Structural Genomics

Comparative modeling in structural genomics.

team research. Moreover, to address fundamental problems in medicine and biology, there is no one tool that can provide all the answers. Thus, in addition to developing specific technologies, a second set of programs is envisioned, focusing on bringing together topicor disease-based expertise with multiple structural methodologies to work on a key problem in medicine and biology. For these team...

Comparative Protein Structure Modeling in Genomics

The function of a protein is generally determined by its three-dimensional (3D) structure. Thus, it would be useful to know 3D structure of the thousands of protein sequences that are emerging from the many genome projects. This is the aim of structural genomics. The aim will be achieved by a focused, large-scale determination of protein structures by X-ray crystallography and nuclear magnetic ...

Bioinformatics in structural genomics.

Comparative Genomics in Eukaryotes

was coined in 1920 (see Chapter 1), the general concept goes back at least as far as the 4th century BCE, when Aristotle implicated blood as the heredity substance. The blood of the mother, it was thought, supplied matter to the developing fetus whereas the semen (a purified form of blood) of the father conveyed form (Aristotle, 1953). Ironically, although the notions of “blood relations” and c...

Comparative genomics of human stem cell factor (SCF)

Stem cell factor (SCF) is a critical protein with key roles in the cell such as hematopoiesis, gametogenesis and melanogenesis. In the present study a comparative analysis on nucleotide sequences of SCF was performed in Humanoids using bioinformatics tools including NCBI-BLAST, MEGA6, and JBrowse. Our analysis of nucleotide sequences to find closely evolved organisms with high similarity by NCB...